🔑 Hirschsprung's Disease is a congenital condition where the nerve cells of the myoenteric plexus are absent in the distal bowel and rectum.
🌐 The myenteric plexus, also known as Auerbach's plexus, forms the enteric nervous system and runs along the bowel wall.
⚙️ The myenteric plexus is responsible for stimulating the movement of the bowels and is composed of neurons, ganglion cells, receptors, synapses, and neurotransmitters.
🔑 Hirschsprung's Disease is characterized by the absence of parasympathetic ganglion cells in the distal colon and rectum.
⚙️ During fetal development, these ganglion cells migrate down to the distal colon, but in Hirschsprung's Disease, they do not fully reach the end.
💡 The length of the colon without ganglion cells can vary, ranging from a small area to the entire colon.
💡 Hirschsprung's Disease is a condition where a section of the colon does not relax, leading to feces obstruction and bowel distention.
🧬 Genetics play a role in the development of Hirschsprung's Disease, with certain genes on different chromosomes increasing the risk. A family history of the disease also contributes to the risk.
🔀 Hirschsprung's Disease is often found in isolation, but it can be associated with other syndromes, including Down syndrome.
🧬 Hirschsprung's Disease is a genetic condition that affects the bowel.
⚠️ The severity and age at diagnosis of Hirschsprung's Disease vary depending on the individual.
🤔 Symptoms of Hirschsprung's Disease include intestinal obstruction, constipation, abdominal pain, vomiting, and poor weight gain.
🔍 Hirschsprung's Disease is inflammation and obstruction of the intestine.
⚠️ It presents with fever, abdominal distension, diarrhea with blood, and sepsis features.
💡 Diagnosis is confirmed through an abdominal x-ray and rectal biopsy.
⭐ Hirschsprung's Disease is a condition that affects children and causes intestinal obstruction.
💉 Initial fluid resuscitation and management of the intestinal obstruction are required for children with Hirschsprung's Disease.
🔬 Surgical removal of the affected section of the bowel is the definitive management for Hirschsprung's Disease.
📚 Hirschsprung's Disease is a condition that affects the large intestine and causes problems with bowel movements.
🔍 Symptoms of Hirschsprung's Disease include constipation, abdominal distension, and failure to pass meconium.
🏥 Diagnosis of Hirschsprung's Disease can be done through a physical examination, imaging tests, and biopsy.
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