🌼 For over 3000 years, the opium poppy has been used for its pain-relieving properties.
💉 During the 19th and 20th centuries, synthetic opioids like morphine and heroin were developed.
💊 Opioids, whether natural or synthetic, are highly effective painkillers but can be addictive.
💊 In the 80s and 90s, pharmaceutical companies heavily marketed opioid painkillers, leading to a rise in prescription rates and addiction cases.
🧠 Opioid drugs bind to opioid receptors in the brain, mimicking the natural pain relief process of endorphins but with stronger and longer-lasting effects.
😫 Opioids not only relieve pain, but also affect mood and various bodily functions, with their potency and duration of action surpassing that of naturally occurring molecules in the body.
🧠 Opioid drugs stimulate the release of dopamine, which is responsible for feelings of pleasure and euphoria.
💉 Opioid substances inhibit the release of norepinephrine, affecting alertness, respiration, digestion, and blood pressure.
🔄 Over time, the body develops tolerance to opioids, requiring higher and higher doses to achieve the same effects.
🧠 Opioid addiction is caused by an excessive sensitivity to norepinephrine.
⚖️ Stopping opioid use suddenly disrupts the balance and leads to withdrawal symptoms.
⌛ The body takes time to get rid of excess norepinephrine, resulting in a period of extreme sensitivity and withdrawal symptoms.
💡 Opioid addiction and overdose cases have been increasing in the US and worldwide.
⚠️ Prescription opioids are becoming more regulated, but cases of overdose and addiction, especially among young people, are still rising.
🔑 Naloxone is an effective defense against opioid overdose as it blocks the opioid receptors and reverses excessive doses.
🔑 Opioid addiction treatment programs can be costly and have long waiting lists.
🌡️ Withdrawal and prolonged residential stays are challenging for individuals at risk of losing their jobs and housing.
💊 Medications like methadone and buprenorphine are commonly used in opioid addiction treatment.
🔑 Opioid addiction is a serious problem, with a growing black market.
🌍 There is hope to combat opioid addiction through various treatments and support services.
☎️ If you or someone you know is struggling with opioid addiction in the United States, seek help from the Department of Health and Human Services.
Milind Katti Co-founder & CEO of DemandFarm
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