Routes of Drug Administration: Exploring Absorption and Bioavailability
This bonus lesson explores the impact of different routes of drug administration on absorption and bioavailability, including advantages and disadvantages.
00:00:00 This bonus lesson discusses the influence of administration routes on drug absorption and bioavailability. Administration via oral route results in first-pass metabolism in the liver, leading to reduced bioavailability.
Biodisponibilidade e vias de administração influenciam a absorção de medicamentos.
Medicamentos administrados oralmente são metabolizados no fígado, reduzindo sua quantidade na circulação sistêmica.
Administrar medicamentos diretamente na corrente sanguínea evita o metabolismo de primeira passagem, aumentando sua biodisponibilidade.
00:02:02 Learn about different routes of drug administration, their advantages, disadvantages, and their relationship with bioavailability.
🔑 Different routes of administration affect the absorption and availability of a medication.
💊 Oral administration is convenient, safe, and cost-effective.
💉 Intravenous administration provides 100% availability but requires professional assistance.
00:04:05 This video discusses different routes of administration for medications and their advantages and disadvantages, including the impact of first-pass effect on bioavailability. It also mentions factors that can affect drug absorption and the limitations of oral administration.
📚 The passage of medication through the liver can affect its bioavailability and is known as first-pass effect.
⏰ Oral administration may not be suitable for emergency situations as it takes time for the medication to dissolve and pass through the liver.
💊 Certain medications may have adverse effects on the gastrointestinal tract when administered orally, but some tablets have a coating to protect the stomach.
00:06:08 This video discusses different routes of administration for medications, including sublingual, rectal, and parenteral routes. It highlights the advantages and disadvantages of each route.
🔑 Different routes of drug administration have their advantages and disadvantages.
🔑 The enteral routes include sublingual and rectal administration, with the latter allowing for direct absorption into the bloodstream.
🔑 The parenteral routes, such as intravenous administration, provide immediate drug action but carry risks of errors and complications.
00:08:11 This video discusses the different routes of administration for medications, including intramuscular and subcutaneous routes. It explains the advantages and disadvantages of each route and their impact on drug absorption and duration of action.
🔍 Intramuscular administration allows for slow absorption into the bloodstream and is safe and effective.
💉 Subcutaneous administration provides constant and gradual release of medication, but may cause irritation.
🧠 Intra-arterial administration is challenging to pass the blood-brain barrier but provides rapid action in the brain and spinal cord.
00:10:14 This video discusses different routes of medication administration, including administration in the spinal space, through inhalation, and via the skin. Each route has its advantages and disadvantages in terms of absorption and potential side effects.
💉 The video discusses different routes of drug administration, including intrathecal and arterial routes.
🫁 The pulmonary route allows for the administration of gas and volatile medications, either systemically or locally.
👩⚕️ Transdermal administration involves absorption through the skin, with advantages such as direct entry into the bloodstream and slow release of medication.
🖐️ Topical application can be confusing, but it refers to the application of medication on the skin.
00:12:17 An overview of topical routes of drug administration, including dermatological, ophthalmological, nasal, dental, and vaginal routes. Topical administration leads to faster onset of action and avoids first-pass metabolism.
🔍 There are various types of topical administration, including dermatological, ophthalmic, nasal, dental, and vaginal.
⏰ Topical administration offers faster onset of action and avoids the first-pass effect.
📚 Understanding the different routes of administration in pharmacology will provide a deeper understanding of the topic.
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