Understanding Fungi Recognition and Immune Response Activation
The video explores the recognition of fungi and activation of immune response in host defenses against fungal pathogens.
00:00:03 The video discusses the recognition of fungi and activation of immune response in host defenses against fungal pathogens.
🍄 Recognition of fungi and activation of immune response are the initial steps in antifungal host defenses.
🌬️ Airborne fungi like Aspergillus and Zygomycetes can be encountered in the respiratory tract, while Candida is found in cutaneous, mucosal, and gastrointestinal sites.
💉 Fungi can invade the bloodstream and other body parts through various means, such as catheter insertion sites and mucosal injury.
00:01:07 Recognition of fungi by immune cells activates signaling cascades and transcription of cytokines and chemokines. Immune cells are recruited to infected and damaged tissue.
🔍 Recognition of fungi is facilitated by pattern recognition and opsonic receptors.
🔬 Fungi and fungal particles bind to macrophages and dendritic cells, activating intracellular signaling.
🌪️ Cytokines and chemokines are synthesized and released, activating immune cells and recruiting them to infected tissue.
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