Controversial debate: LDL cholesterol and cardiovascular disease

🔑 LDL cholesterol is causative of atherosclerosis and is linked to cardiovascular disease.

🧪 Lowering LDL cholesterol has been shown to improve outcomes in cardiovascular disease.

⚠️ The correlation between LDL cholesterol and cardiovascular disease varies based on insulin sensitivity and resistance.

🔑 LDL corrected for LP little a is not predictive for cardiovascular disease.

📊 Metabolic unwellness confuses the association between LDL and cardiovascular disease.

💡 Insulin resistance and increased susceptibility of LDL for oxidation are the real targets.

📝 LDL cholesterol may not be a reliable risk factor for cardiovascular disease when considering insulin sensitivity.

💡 LP little a and oxidized LDL may be better indicators of cardiovascular risk.

❗ Low HDL and high triglycerides are associated with metabolic syndrome and cardiovascular risk.

🔑 LDL particles are retained in the arterial wall, indicating a possible error of judgment in attributing atherosclerosis solely to LDL.

🔄 Atherosclerosis is a complex process involving factors like aggregation, oxidation, and uptake by macrophages, not just LDL alone.

🧪 Increased intake of linoleic acid and seed oils may lead to LDL oxidation in the sub-endothelial space, which is considered problematic.

🔑 Consuming oils high in linoleic acid increases the breakdown products of LDL oxidation.

⚠️ Higher intake of saturated fat reduces LP little a, a major risk factor for cardiovascular disease.

🔬 Studies show that consuming soybean oil increases lppla2, a particle associated with the cleaving of oxidized phospholipids in LDL.

📊 A study with 68,000 participants showed that seed oil consumption led to a reduction in cardiovascular mortality and strokes.

🔬 Adipose tissue linoleic acid is an accurate measure for cardiovascular disease, and studies show that higher levels of linoleic acid in adipose tissue are associated with worse cardiovascular health.

🚫 There is no direct correlation between saturated fat and cardiovascular disease, as shown by systematic reviews and meta-analyses on butter consumption.

⚡️ Conflicting evidence on the relationship between saturated fat and cardiovascular disease and the need to assess the quality of individual studies.

🔍 Free-living populations with low rates of cardiovascular disease and chronic disease have different dietary habits, including meat, organs, dairy, and honey, while avoiding seed oils.

🥩 Animal-based diets can improve insulin sensitivity, metabolic health, and provide essential nutrients, challenging the fear of LDL in the context of metabolic health.