Routes of Drug Administration: Exploring Absorption and Bioavailability

Biodisponibilidade e vias de administração influenciam a absorção de medicamentos.

Medicamentos administrados oralmente são metabolizados no fígado, reduzindo sua quantidade na circulação sistêmica.

Administrar medicamentos diretamente na corrente sanguínea evita o metabolismo de primeira passagem, aumentando sua biodisponibilidade.

🔑 Different routes of administration affect the absorption and availability of a medication.

💊 Oral administration is convenient, safe, and cost-effective.

💉 Intravenous administration provides 100% availability but requires professional assistance.

📚 The passage of medication through the liver can affect its bioavailability and is known as first-pass effect.

⏰ Oral administration may not be suitable for emergency situations as it takes time for the medication to dissolve and pass through the liver.

💊 Certain medications may have adverse effects on the gastrointestinal tract when administered orally, but some tablets have a coating to protect the stomach.

🔑 Different routes of drug administration have their advantages and disadvantages.

🔑 The enteral routes include sublingual and rectal administration, with the latter allowing for direct absorption into the bloodstream.

🔑 The parenteral routes, such as intravenous administration, provide immediate drug action but carry risks of errors and complications.

🔍 Intramuscular administration allows for slow absorption into the bloodstream and is safe and effective.

💉 Subcutaneous administration provides constant and gradual release of medication, but may cause irritation.

🧠 Intra-arterial administration is challenging to pass the blood-brain barrier but provides rapid action in the brain and spinal cord.

💉 The video discusses different routes of drug administration, including intrathecal and arterial routes.

🫁 The pulmonary route allows for the administration of gas and volatile medications, either systemically or locally.

👩‍⚕️ Transdermal administration involves absorption through the skin, with advantages such as direct entry into the bloodstream and slow release of medication.

🖐️ Topical application can be confusing, but it refers to the application of medication on the skin.

🔍 There are various types of topical administration, including dermatological, ophthalmic, nasal, dental, and vaginal.

⏰ Topical administration offers faster onset of action and avoids the first-pass effect.

📚 Understanding the different routes of administration in pharmacology will provide a deeper understanding of the topic.